Process improvements for the preparation of kilo quantities of a series of isoindoline compounds

TJ Watson, TA Ayers, N Shah, D Wenstrup…

Index: Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P. Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532

Full Text: HTML

Citation Number: 27

Abstract

A series of isoindoline analogues with either an indazole (HMR 2934, HMR 2651) or benzisoxazole (HMR 2543) appendage were prepared for the proposed treatment of psychiatric disorders such as obsessive compulsive disorder and attention deficit disorder. The isoindoline compounds were prepared by reduction of the corresponding phthalimides with LiAlH4. One compound was not chiral, and the other two required an enantioselective ...

Related Articles:

A novel type of PdMC-catalyzed hydrogenation using a catalyst poison: Chemoselective inhibition of the hydrogenolysis for O-benzyl protective group by the addition …

[Sajiki, Hironao; Hirota, Kosaku Tetrahedron, 1998 , vol. 54, # 46 p. 13981 - 13996]

Acceleration of the N. ALPHA.-Deprotection Rate by the Addition of m-Cresol to Diluted Methanesulfonic Acid and Its Application to the Z (OMe)-Based Solid-Phase …

[Tamamura; Nakamura; Noguchi; Funakoshi; Fujii Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 5 p. 954 - 957]

A novel type of PdMC-catalyzed hydrogenation using a catalyst poison: Chemoselective inhibition of the hydrogenolysis for O-benzyl protective group by the addition …

[Sajiki, Hironao; Hirota, Kosaku Tetrahedron, 1998 , vol. 54, # 46 p. 13981 - 13996]

Amine–boranes: effective reducing agents for the deracemisation of dl-amino acids using l-amino acid oxidase from Proteus myxofaciens

[Alexandre, Francois-Rene; Pantaleone, David P.; Taylor, Paul P.; Fotheringham, Ian G.; Ager, David J.; Turner, Nicholas J. Tetrahedron Letters, 2002 , vol. 43, # 4 p. 707 - 710]

Synthesis of N??phthaloyl??L??serine??t. butyl ester

[de Haas,G.H.; van Deenen,L.L.M. Recueil des Travaux Chimiques des Pays-Bas, 1962 , vol. 81, p. 215 - 218]

More Articles...