Journal of the American Chemical Society

Catalytic direct β-arylation of simple ketones with aryl iodides

Z Huang, G Dong

Index: Huang, Zhongxing; Dong, Guangbin Journal of the American Chemical Society, 2013 , vol. 135, # 47 p. 17747 - 17750

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Citation Number: 25

Abstract

Herein we report a direct β-arylation of simple ketones with widely available aryl iodides, combining palladium-catalyzed ketone oxidation, aryl-halide activation, and conjugate addition through a single catalytic cycle. Simple cyclic ketones with different ring-sizes, as well as acyclic ketones, can be directly arylated at the β-position with complete site- selectivity and excellent functional group tolerance.

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