Tetrahedron

Copper catalyzed conjugate addition of highly functionalized arylmagnesium compounds to enones

G Varchi, A Ricci, G Cahiez, P Knochel

Index: Varchi, Greta; Ricci, Alfredo; Cahiez, Gerard; Knochel, Paul Tetrahedron, 2000 , vol. 56, # 18 p. 2727 - 2731

Full Text: HTML

Citation Number: 34

Abstract

Highly functionalized arylmagnesium bromides are readily prepared by an iodine– magnesium exchange reaction. In the presence of catalytic amounts of copper (I) salts and chlorotrimethylsilane, they add to various enones leading to the conjugate addition products in 66–89% yield.

Related Articles:

Preparation of highly functionalized magnesium, zinc, and copper aryl and alkenyl organometallics via the corresponding organolithiums

[Tucker, Charles E.; Majid, Tahir N.; Knochel, Paul Journal of the American Chemical Society, 1992 , vol. 114, # 10 p. 3983 - 3985]

Organo [2-(hydroxymethyl) phenyl] dimethylsilanes as mild and reproducible agents for rhodium-catalyzed 1, 4-addition reactions

[Nakao, Yoshiaki; Chen, Jinshui; Imanaka, Hidekazu; Hiyama, Tamejiro; Ichikawa, Yoshitaka; Duan, Wei-Liang; Shintani, Ryo; Hayashi, Tamio Journal of the American Chemical Society, 2007 , vol. 129, # 29 p. 9137 - 9143]

Catalytic direct β-arylation of simple ketones with aryl iodides

[Huang, Zhongxing; Dong, Guangbin Journal of the American Chemical Society, 2013 , vol. 135, # 47 p. 17747 - 17750]

More Articles...