Tetrahedron letters

Base assisted substitution of α-amidoalkyl sulfones by nitromethane anion. A new entry to functionalized α-amino acids

R Ballini, M Petrini

Index: Ballini, Roberto; Petrini, Marino Tetrahedron Letters, 1999 , vol. 40, # 23 p. 4449 - 4452

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Citation Number: 43

Abstract

Typical experimental procedure for preparation of nitrocompounds2: To a stirred suspension of NaH (25 mmol) in dry THF (15 mL), nitromethane (25 mmol) is added dropwise at room temperature. After stirring for 30 min, sulfone 1 4,5 (5 mmol) dissolved in dry THF (5 mL) is added and the white suspension is stirred for 1 h at room temperature. The reaction mixture is diluted with chloroform (50 mL) and washed with saturated ammonium chloride. The organic ...