Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest

D Rambabu, GP Kumar, BD Kumar, R Kapavarapu…

Index: Rambabu; Kumar, G. Pavan; Kumar, Barange Deepak; Kapavarapu, Ravikumar; Rao, M.V. Basaveswara; Pal, Manojit Tetrahedron Letters, 2013 , vol. 54, # 23 p. 2989 - 2995

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Citation Number: 12

Abstract

The coupling of o-bromobenzoic acid with terminal alkynes using 10% Pd/C–Et3N–CuI– PPh3 as a catalyst system leads to the synthesis of (Z)-3-alkylidenephthalides as the major product along with the traces of isocoumarin when the reaction was performed in 1, 4- dioxane. The methodology afforded a range of compounds including (Z)-3-(4- (methylsulfonyl) benzylidene) isobenzofuran-1 (3H)-one of potential pharmacological ...

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