The Journal of Organic Chemistry

Acidic Cleavage of Amino [1, 2, 5] thiadiazolo [3, 4-d]-and-v-triazolo [4, 5-d] pyrimidines to 1, 2, 5-Thiadiazole-1 and v-Triazolecarboxamidines2

YF Shealy, CA O'Dell

Index: Shealy,Y.F.; O'Dell,C.A. Journal of Organic Chemistry, 1965 , vol. 30, p. 2488 - 2490

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Citation Number: 6

Abstract

The pyrimidine ring of 7-amino [1, 2, 5] thiadiazolo [3, 4-d] pyrimidine (Ia) has been opened by aqueous base and by primary amines, the latter agents producing N-alkyl carboxamidines. During studies on possible modes of ring cleavage, 7-pyrrolidino [1, 2, 5 Ithiadiazolo [3, 4-d] pyrimidine (IC) was treated with dilute hydrochloric acid in dioxane at 85". The product had the composition of the hydrochloride of the amino carboxamidine IIc, ...