The Journal of Organic Chemistry

Thiadiazoles. III. Amino-Group Exchange and Ring-Cleavage Reactions of 7-Amino [1, 2, 5] thiadiazolo [3, 4-d] pyrimidines1

YF Shealy, CA O'Dell

Index: Shealy,Y.F.; O'Dell,C.A. Journal of Organic Chemistry, 1964 , vol. 29, p. 2135 - 2141

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Citation Number: 7

Abstract

Displacement of the amino group of 7-amino [1, 2, 5] thiadiazolo [3, 4-d] pyrimidine (I) by secondary amines was shown to occur with the formation of 7-(disubstituted amino)[1, 2, 5] thiadiazolo [3, 4-d] pyrimidines(V-VIII). Primary amines were likewise shown to effect displacement of the amino group, but cleavage of the pyrimidine ring to a 1, 2, 5-thiadiazole may ensue. The structure of the amino-group exchange product from I and butylamine ...