Novel alkoxyamine linker to load ketones for solid-phase synthesis: application of the synthesis of 1, 4-benzodiazepine-2-ones

K Matsushita, C Okamoto, M Yoshimoto…

Index: Matsushita, Kimihito; Okamoto, Chieko; Yoshimoto, Mayumi; Harada, Kenichi; Kubo, Miwa; Fukuyama, Yoshiyasu; Hioki, Hideaki Journal of Combinatorial Chemistry, 2010 , vol. 12, # 3 p. 311 - 314

Full Text: HTML

Citation Number: 6

Abstract

Selection of an adequate linker is important for the solidphase organic synthesis. Linkers should be easy to load scaffolds onto the solid support, and must be not only stable during the reactions but also cleavable without product damage at the final stage. Much effort has been made to design and synthesize various linkers suitable for loading the scaffolds, as well as for giving desired products. 1 We have previously developed the new ...