Synthesis

Reaction of Huisgen Zwitterion with Diaryl Ketones Leading to the Facile Synthesis of Mono-and Bis (alkoxycarbonyl) hydrazones

V Nair, SC Mathew, AT Biju, E Suresh

Index: Nair, Vijay; Mathew, Smitha C.; Biju, Akkattu T.; Suresh, Eringathodi Synthesis, 2008 , # 7 p. 1078 - 1084

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Citation Number: 6

Abstract

The reaction of electrophiles with zwitterions generated from phosphines and activated carbon-carbon multiple bonds has emerged as an efficient synthetic strategy for the construction of carbon-carbon and carbon-heteroatom bonds. [1] Although the zwitterion formed by the addition of triphenylphosphine to dialkyl azodicarboxylate, commonly known as the Huisgen zwitterion (Scheme [1] ), [2] has found extensive use as the pivotal intermediate in the well-known ...