European Journal of Organic Chemistry

Regioselectivity in the Addition of Grignard Reagents to Bis (2??benzothiazolyl) Ketone: C??vs. O??Alkylation Using Aryl Grignard Reagents

C Boga, G Micheletti

Index: Boga, Carla; Micheletti, Gabriele European Journal of Organic Chemistry, 2010 , # 29 p. 5659 - 5665

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Abstract

Abstract The reaction between bis (2-benzothiazolyl) ketone (1) and a series of ring- substituted phenyl Grignard reagents gives, in considerable amount, the unexpected O- alkylation product derived from the attack of the Grignard reagent to thecarbonyl oxygen atom, thus extending the range of rarely reported cases in which O-alkylation can occur. The expected classic 1, 2-addition product and that derived from O-alkylation have been ...