Indolspaltung bei Mebhydrolin durch Natriumperiodat–2. Mitt. Mechanismus der Dilactam-Bildung

H Möhrle, C Rohn, G Westle

Index: Moehrle; Rohn; Westle Pharmazie, 2006 , vol. 61, # 5 p. 391 - 399

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Abstract

Aus den γ-Carbolinen 1a–d entstanden mit Periodat unter 1C-Verlust—ohne fassbare Praecursoren—die Achtring-dilactame 3a–c und die Aminosäure 9d. Als mögliche Intermediate einer Indolspaltung wurden α-Aminoketone als Modelle untersucht, wobei

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