Tetrahedron

A flexible synthesis of carbanucleosides and 5′-nor-1′-homo carbanucleosides from a common precursor

VP Rajappan, X Yin, SW Schneller

Index: Rajappan, Vasathakumar P; Yin, Xueqiang; Schneller, Stewart W Tetrahedron, 2002 , vol. 58, # 49 p. 9889 - 9895

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Citation Number: 19

Abstract

Enzymatic resolution of (±)-1-acetoxy-4-(nitromethyl)-2-cyclopentene (4) provides entry into a facile 10-step route to carbanucleosides and a practical 7-step procedure to 5′-nor-1′- homo carbanucleosides. These routes are illustrated for adenine derivatives but they are adaptable to any heterocyclic base.

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