Aristeromycin

Modify Date: 2024-01-05 21:52:37

Aristeromycin structure	Common Name	Aristeromycin
	CAS Number	19186-33-5	Molecular Weight	265.26900
	Density	1.92g/cm3	Boiling Point	595.1ºC at 760mmHg
	Molecular Formula	C₁₁H₁₅N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	313.7ºC

Use of Aristeromycin

Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2].

Name	Aristeromycin
Synonym	More Synonyms

Description	Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	S-adenosylhomocysteine hydrolase[1]
In Vitro	The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM SAH (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1]. Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1]. At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1].
References	[1]. Uchiyama N, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146. [2]. Ishikura T, et al. Inhibition of S-adenosylhomocysteine hydrolase by purine nucleoside analogues. Nucleic Acids Symp Ser. 1983;(12):119-22.

Density	1.92g/cm3
Boiling Point	595.1ºC at 760mmHg
Molecular Formula	C₁₁H₁₅N₅O₃
Molecular Weight	265.26900
Flash Point	313.7ºC
Exact Mass	265.11700
PSA	130.31000
Vapour Pressure	5.19E-15mmHg at 25°C
Index of Refraction	1.881
Storage condition	-20°C

WGK Germany	3
RTECS	GY4250000

Precursor 4
CAS#:84955-45-3 (1R,2S,3R,4R)-4... CAS#:85026-57-9 (1R,2S,3R,4S)-2... CAS#:84955-46-4 (1R,2S,3R,4R)-4... CAS#:683276-43-9 (4R,5R)-1-(2,2-...
DownStream 1
CAS#:16975-94-3 6H-Purin-6-one,...

Cycloadenosine

carbocyclic adenosine

4'-O-Carbaadenosine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,2-Cyclopentanediol,5-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-, (1S,2R,3R,5R)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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