Design, synthesis and in vitro antibacterial and antifungal activities of some novel spiro [azetidine-2, 3′-indole]-2, 4 (1′ H)-dione

…, NR Modi, MJ Patel, LJ Patel, BF Chauhan…

Index: Shah, Ravi J.; Modi, Neha R.; Patel, Manish J.; Patel, Laxmanbhai J.; Chauhan, Bhupendrasinh F.; Patel, Madhabhai M. Medicinal Chemistry Research, 2011 , vol. 20, # 5 p. 587 - 594

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Citation Number: 12

Abstract

Abstract The present study deals with the synthesis of novel spiro [azetidine-2, 3′-indole]- 2′, 4 (1′ H)-dione derivative from the reactions of 3-(phenylimino)-1, 3-dihydro-2H-indol-2- one derivatives with chloracetyl chloride in the presence of triethylamine (TEA). All the compounds were characterized using IR, 1 H-NMR, MS, and elemental analysis. They were screened for their antibacterial and antifungal activities. The bacterial strains used were ...