Synlett

Chlorination of nucleosides by N-chlorodiisopropylamine and triphenylphosphine

YS Zhou, ZW Miao, YF Zhao

Index: Zhou, Yi-Sui; Miao; Zhao, Yu-Fen Synlett, 2000 , # 5 p. 671 - 673

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Citation Number: 8

Abstract

Abstract: The combination of N-chlorodiisopropylamine and triphenylphosphine (1) was exploited as a new method for chlorination of the hydroxyl group on the nucleosides. A possible mechanism involving an oxyphosphonium intermediate 2a and a phosphorane