RuHCl (CO)(PPh3) 3-Catalyzed Reductive Dimerization of α, β-Unsaturated Aldehydes Leading to α-Hydroxymethyl Ketones

T Doi, T Fukuyama, S Minamino, I Ryu

Index: Doi, Takashi; Fukuyama, Takahide; Minamino, Satoshi; Ryu, Ilhyong Synlett, 2006 , # 18 p. 3013 - 3016

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Citation Number: 17

Abstract

Abstract The reductive dimerization α, β-unsaturated aldehydes to give saturated ketones was achieved using RuHCl (CO)(PPh 3) 3 as a catalyst in the presence of secondary alcohols as hydrogen source. The reaction is likely to proceed via the hydroruthenation of α, β-unsaturated aldehydes followed by aldol reaction of the resultant ruthenium enolates with α, β-unsaturated aldehydes to give unsaturated α-hydroxymethyl ketones, which undergo ...