5-imino-1, 2, 4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3
…, A Castro, NE Campillo, A Perez-Castillo…
Index: Palomo, Valle; Perez, Daniel I.; Perez, Concepcion; Morales-Garcia, Jose A.; Soteras, Ignacio; Alonso-Gil, Sandra; Encinas, Arantxa; Castro, Ana; Campillo, Nuria E.; Perez-Castillo, Ana; Gil, Carmen; Martinez, Ana Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1645 - 1661
Full Text: HTML
Citation Number: 40
Abstract
Cumulative evidence strongly supports that glycogen synthase kinase-3 (GSK-3) is a pathogenic molecule when it is up-dysregulated, emerging as an important therapeutic target in severe unmet human diseases. GSK-3 specific inhibitors might be promising effective drugs for the treatment of devastating pathologies such as neurodegenerative diseases, stroke, and mood disorders. As GSK-3 has the ability to phosphorylate primed ...
Related Articles:
[Wang, Wentao; Cong, Yu; Zhang, Leilei; Huang, Yanqiang; Wang, Xiaodong; Zhang, Tao Tetrahedron Letters, 2014 , vol. 55, # 1 p. 124 - 127]
[Ueda, Mitsuru; Oikawa, Hideaki Journal of Organic Chemistry, 1985 , vol. 50, # 6 p. 760 - 763]
One pot preparation of amides from azo compounds by Sm/TiCl4
[Li, Xue; Zhang, Yong-Min Journal of the Chinese Chemical Society, 2005 , vol. 52, # 6 p. 1219 - 1222]
One pot preparation of amides from azo compounds by Sm/TiCl4
[Li, Xue; Zhang, Yong-Min Journal of the Chinese Chemical Society, 2005 , vol. 52, # 6 p. 1219 - 1222]
[Sharghi, Hashem; Jokar, Mahboubeh; Doroodmand, Mohammad Mahdi Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 426 - 442]