The mechanism of the bischler??napieralski reaction
S Nagubandi, G Fodor
Index: Nagubandi, Sreeramulu; Fodor, G. Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1457 - 1463
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Citation Number: 38
Abstract
Abstract The Bischler-Napieralski dihydroisoquinoline synthesis was proven to occur via imidoyl chlorides and the corresponding nitrilium salt. The two-step process required much milder conditions (20–50) compared to drastic classical conditions of refluxing at 100–200. The Bischler-Napieralski reaction is shown to share a common intermediate with two other well-known reactions: the von Braun and the Ritter reactions.
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