Organic letters

A versatile cyclodehydration reaction for the synthesis of isoquinoline and β-carboline derivatives

M Movassaghi, MD Hill

Index: Movassaghi, Mohammad; Hill, Matthew D. Organic Letters, 2008 , vol. 10, # 16 p. 3485 - 3488

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Citation Number: 90

Abstract

The direct conversion of various amides to isoquinoline and β-carboline derivatives via mild electrophilic amide activation, with trifluoromethanesulfonic anhydride in the presence of 2- chloropyridine, is described. Low-temperature amide activation followed by cyclodehydration upon warming provides the desired products with short overall reaction times. The successful use of nonactivated and halogenated phenethylene derived amides ...