Phencyclidine-like effects of tetrahydroisoquinolines and related compounds

NM Gray, BK Cheng, SJ Mick, CM Lair…

Index: Gray, Nancy M.; Cheng, Brian K.; Mick, Stephen J.; Lair, Cecelia M.; Contreras, Patricia C. Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1242 - 1248

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Citation Number: 62

Abstract

A series of 1, 2, 3, 4-tetrahydroisoquinolines, tetrahydrothieno [2, 3-~] pyridines, and related compounds were evaluated for their ability to inhibit binding of [3H]-l-[l-(2-thienyl) piperidine and [3H]-N-allylnormetazocine to phencyclidine (PCP) and u receptors, respectively. A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia. All of the ...