Applicability of glutaminyl-tRNA cyclotransferase in the peptide synthesis

V Čeřovský, K Jošt

Index: Cerovsky, Vaclav; Jost, Karel Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 10 p. 2310 - 2318

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Abstract

Abstract Peptides with amino-terminal glutamine and their derivatives on treatment with crude papain preparation, containing glutaminyl-tRNA cyclotransferase (EC 2.3. 2.5.), are converted into the corresponding compounds with pyroglutamic acid. This enzymic cyclization does not take place with glutamic acid or its γ-derivatives. The reaction has been optimized for the preparation of pyroglutamic acid phenylhydrazide. Glutaminyl-leucine ...