Synthesis and nootropic activity of pyrrolidino [1, 2-a] diazacycloalkanes

TA Gudasheva, NI Vasilevich, RU Ostrovskaya…

Index: Gudasheva; Vasilevich; Ostrovskaya; Trofimov; Voronina; Skoldinov; Rozantsev Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 9 p. 562 - 567

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Citation Number: 5

Abstract

Among the proline-containing compounds possessing nootropic properties, the maximum activity was observed for the ethy i ester of N-pheny lacety lproly Iglycine [6]. In this paper we present data on the synthesis of a new group of the pyracetam analogs, pyrrolidino [1, 2-a] diazacycloalkanes, based on the natural pyrrolidine-containing amino acids. We have also studied the antiamnesic activity of the synthesized compounds. We believe that ...