… using sodium sulfide or tetrabutylammonium fluoride. Synthesis of 1, 4-dihydropyridine monocarboxylic acids and unsymmetrical 1, 4-dihydropyridine dicarboxylates
T Ogawa, K Hatayama, H Maeda, Y Kita
Index: Kita; Maeda; Takahashi; Fukui; Ogawa; Hatayama Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 1 p. 147 - 150
Full Text: HTML
Citation Number: 16
Abstract
Several 3-(2-cyanoethyl)-1, 4-dihydropyridine carboxylates (16) were prepared in moderate to good yields by means of the Hantzsch reaction. Treatment of these carboxylates with a weak base such as sodium sulfide or tetrabutylammonium fluoride at room temperature afforded smoothly the corresponding 1, 4-dihydropyridine monocarboxylic acids (18) in good yields. The monocarboxylic acids 18n and 18o were esterified with 2- ...
Related Articles:
t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1
[Journal of the American Chemical Society, , vol. 82, p. 3359 - 3363]
Enzymatic synthesis of activated esters and their subsequent use in enzyme-based peptide synthesis
[Nuijens, Timo; Cusan, Claudia; Schepers, Annette C.H.M.; Kruijtzer, John A.W.; Rijkers, Dirk T.S.; Liskamp, Rob M.J.; Quaedflieg, Peter J.L.M. Journal of Molecular Catalysis B: Enzymatic, 2011 , vol. 71, # 1-2 p. 79 - 84]
Enzyme??Specific Activation versus Leaving Group Ability
[ChemBioChem, , vol. 13, # 12 p. 1785 - 1790]
New approach to the use of 2-bromoethyl esters in peptide synthesis
[Amaral Trigo, M. Joaquina S. A.; Oliveira Santos, M. Isabel A. Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 11B p. 2787 - 2790]
Enzyme??Specific Activation versus Leaving Group Ability
[ChemBioChem, , vol. 13, # 12 p. 1785 - 1790]