Discovery of Benzamide Analogues as a Novel Class of 5??HT3 Receptor Agonists

CG Jørgensen, B Frølund, J Kehler…

Index: Jorgensen, Charlotte G.; Frolund, Bente; Kehler, Jan; Jensen, Anders A. ChemMedChem, 2011 , vol. 6, # 4 p. 725 - 736

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Citation Number: 6

Abstract

Abstract A 5-HT 3 receptor agonist based on a benzamide scaffold was identified in a screening of a small commercial compound library, and an elaborate SAR study originating from this hit was performed. The design, synthesis, and functional characterisation of benzamide analogues at the 5-HT 3 A receptor yielded substantial information concerning the analogues as 5-HT 3 receptor agonists. However, the potencies of the derived ...