A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4

…, T Sarkar, E Hamel, MS do Amaral, DP de Lima

Index: Barbosa, Euzebio G.; Bega, Luis A.S.; Beatriz, Adilson; Sarkar, Taradas; Hamel, Ernest; do Amaral, Marcos S.; de Lima, Denis Pires European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2685 - 2688

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Citation Number: 33

Abstract

Studies examining various spacer groups that link the two aromatic rings of combretastatin A- 4 (CA4) have shown that the biological activity of analogs does not require the cis-stilbene configuration of CA4. Oxygen or nitrogen, carbonyl, methylene and ethylene spacers, for example, are present in CA4 analogs that show good activity. Up to now sulfur was not tested for this purpose. In this article we describe the synthesis of sulfide, sulfoxide and ...