Design, synthesis, and structure–activity relationship studies of conformationally restricted mutilin 14-carbamates

…, C Ling, J Cheng, X Guo, H He, S Ding, Y Yang

Index: Fu, Liqiang; Liu, Xin; Ling, Chenyu; Cheng, Jianjun; Guo, Xingsheng; He, Huili; Ding, Shi; Yang, Yushe Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 814 - 819

Full Text: HTML

Citation Number: 12

Abstract

We report herein the design, synthesis, and structure–activity relationship studies of conformationally restricted mutilin 14-carbamates based on the structure of SB-222734. The antibacterial activities of these newly synthesized compounds were also evaluated and compared with linezolid and retapamulin. Results showed that most of the target compounds exhibit good potency in inhibiting the growth of Gram-positive bacteria including ...