An efficient synthesis of N-substituted indoles from indoline/indoline carboxylic acid via aromatization followed by C–N cross-coupling reaction by using nano copper …
…, G Satish, K Ramesh, K Karnakar, YVD Nageswar
Index: Reddy, K. Harsha Vardhan; Satish; Ramesh; Karnakar; Nageswar Tetrahedron Letters, 2012 , vol. 53, # 24 p. 3061 - 3065
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Citation Number: 28
Abstract
A new and elegant protocol for the synthesis of 1-substituted indoles was developed via aromatization of indoline/indoline carboxylic acid followed by C–N cross-coupling with various aryl halides in the presence of nano CuO as a recyclable catalyst, Cs2CO3 as a base in DMSO at 80° C. 1-Substituted indoles were obtained in good to excellent yields and the catalytic system can be recycled up to four cycles without loss of catalytic activity.
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