An Efficient Ultrasound??Assisted Synthesis of N??Alkyl Derivatives of Carbazole, Indole, and Phenothiazine

S Zhao, J Kang, Y Du, J Kang, X Zhao…

Index: Zhao, Sanhu; Kang, Jin; Du, Yuting; Kang, Jingyan; Zhao, Xiaoni; Xu, Yinfeng; Chen, Ruixi; Wang, Qianqian; Shi, Xitao Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 3 p. 683 - 689

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Abstract

Abstract Heterocyclic compounds bearing an acidic hydrogen atom attached to nitrogen such as carbazole, indole, and phenothiazine can be efficiently alkylated in DMSO or N, N- DMF under ultrasonic irradiation in the presence of potassium hydroxide as a base. In almost all cases, a dramatic reduction of the reaction time results and a clear yield increase accompanied by an improved quality of the products occurs.

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