An Efficient Process for Synthesis of 2′-O-methyl and 3′-O-methyl Guanosine from 2-aminoadenosine Using Diazomethane and the Catalyst Stannous Chloride

AR Kore, G Parmar, S Reddy

Index: Kore, Anilkumar; Parmar, Gaurang; Reddy, Srinu Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 3 p. 307 - 314

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Citation Number: 7

Abstract

An improved strategy for the selective synthesis of 2′-O-methyl and 3′-O-methyl guanosine from 2-aminoadenosine is reported by using the catalyst stannous chloride. The regioselectivity of the 2′ and 3′-O-alkylation was achieved by optimizing the addition, timing, and concentration of the catalysts and diazomethane during the methylation reaction. An efficient and selective alkylation at 2′-OH of 2-aminoadenosine was achieved by ...