An Efficient Process for Synthesis of 2′-O-methyl and 3′-O-methyl Guanosine from 2-aminoadenosine Using Diazomethane and the Catalyst Stannous Chloride

AR Kore, G Parmar, S Reddy

Index: Nucleosides, Nucleotides and Nucleic Acids, , vol. 25, # 3 p. 307 - 314

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Citation Number: 7

Abstract

... methoxy-2-pyrimidinone 1-β -D-ribofuranoside into 2′-O-methyl nucleoside components of ... stannous chloride catalyzed monomethylation of the cis-glycol system of nucleosides by diazomethane ... for the simultaneous protection of the 3′ and 5′ hydroxyl groups of nucleotides. ...