Highly Asymmetric NHC??Catalyzed Hydroacylation of Unactivated Alkenes

I Piel, M Steinmetz, K Hirano, R Fröhlich…

Index: Piel, Isabel; Steinmetz, Marc; Hirano, Keiichi; Froehlich, Roland; Grimme, Stefan; Glorius, Frank Angewandte Chemie - International Edition, 2011 , vol. 50, # 21 p. 4983 - 4987

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Citation Number: 100

Abstract

N-Heterocyclic carbene (NHC)-catalyzed umpolung reactions [1] offer an elegant access to several important classes of compounds, such as benzoins [2] or g-butyrolactones.[3] In addition, Enders et al.[4] and Rovis et al.[5] have pioneered the development of a powerful NHC-catalyzed formation of highly functionalized chromanones by an intramolecular Stetter reaction.[6] Recently, we have reported the NHC-catalyzed hydroacylation of unactivated ...