Potential antidepressants: 1-(4-Aminoalkoxy) phenyl)-2-propylamines

V Kmoníček, Z Vejdělek, J Holubek…

Index: Kmonicek, Vojtech; Vejdelek, Zdenek; Holubek, Jiri; Valchar, Martin; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 6 p. 1721 - 1733

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Citation Number: 2

Abstract

Abstract 1-(4-Hydroxyphenyl)-2-propylamine (X) and its N-monomethyl (XI) and N, N- dimethyl (XII) derivatives were O-alkylated with six tert. aminoalkyl chlorides to aminoalkyl ethers Ia-VIc. In cases of X and XI the reactions were complicated by O, N-dialkylation leading to isolation of triamino ethers XVI and XVII. 1-(4-Hydroxyphenyl) propan-2-one was alkylated with 2-dimethylaminoethyl chloride and the ether XIII was obtained. An attempt ...