A One-Pot Azido Reductive Tandem Mono-N-Alkylation Employing Dialkylboron Triflates: Online ESI-MS Mechanistic Investigation

…, V Srinivasulu, K Sreekanth, CS Reddy…

Index: Shankaraiah, Nagula; Markandeya, Nagula; Srinivasulu, Vunnam; Sreekanth, Kokkonda; Reddy, Ch. Sanjeeva; Santos, Leonardo S.; Kamal, Ahmed Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7017 - 7026

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Citation Number: 13

Abstract

An efficient one-pot reductive tandem mono-N-alkylation of both aromatic and aliphatic azides using dialkylboron triflates as alkylating agents has been examined under standardized reaction conditions. This methodology after optimization has been employed toward the syntheses of various secondary alkyl as well as aryl amines, including the synthesis of N10-butylated pyrrolo [2, 1-c][1, 4] benzodiazepine-5, 11-diones via in situ ...

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