Tetrahedron

Synthesis of antimalarial compounds fosmidomycin and FR900098 through N-or P-alkylation reactions

S Suresh, D Shyamraj, M Larhed

Index: Suresh, Surisetti; Shyamraj, Dharavath; Larhed, Mats Tetrahedron, 2013 , vol. 69, # 3 p. 1183 - 1188

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Citation Number: 2

Abstract

Two straightforward and convenient routes for the synthesis of the antimalarial agents FR900098 and fosmidomycin are described. In the key steps N-or P-alkylation reactions are used. The best overall yields of FR900098 and fosmidomycin in 15 mmol scale are 83% and 68%, respectively. These routes utilize readily available materials and avoid harsh conditions.