Synthesis of poly (ethylene glycol) block copolymers as potential water-soluble drug carriers

M Pechar, J Strohalm, K Ulbrich

Index: Pechar, Michal; Strohalm, Jiri; Ulbrich, Karel Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 10 p. 1765 - 1780

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Citation Number: 15

Abstract

Abstract The synthesis of a model water-soluble drug carrier based on poly (ethylene glycol)(PEG) block copolymers is described. In the copolymers, two blocks of PEG are linked by a biodegradable oligopeptide or amino acid linkage containing the glutamic acid residue. 4-Nitroaniline as a drug model is attached to the γ-carboxyl group of glutamic acid of the polymer carrier via an enzymatically degradable oligopeptide spacer. The oligopeptides ...