A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor

L Malet-Sanz, J Madrzak, RS Holvey, T Underwood

Index: Malet-Sanz, Laia; Madrzak, Julia; Holvey, Rhian S.; Underwood, Toby Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7263 - 7267

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Citation Number: 31

Abstract

Interest within the synthetic community in continuous flow processes is rapidly increasing. Its advantages include precise control of the reaction variables, increased safety parameters and ready scale-up of the reaction procedures. 1 Flow methods thus allow highly reactive functionalities to be processed in a well-controlled environment. 2 It therefore represents an attractive option for, amongst others, the pharmaceutical industry where safe, reliable and scalable ...