Synthesis and biological evaluation of nitric oxide-donating analogues of sulindac for prostate cancer treatment

…, JA Ross, FK Habib, NP Botting, D O'Hagan

Index: Nortcliffe, Andrew; Ekstrom, Alexander G.; Black, James R.; Ross, James A.; Habib, Fouad K.; Botting, Nigel P.; O'Hagan, David Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 756 - 761

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Citation Number: 11

Abstract

Abstract A series of analogues of the non-steroidal anti-inflammatory drug (NSAID) sulindac 1 were synthesised tethered to nitric oxide (NO) donating functional groups. Sulindac shows antiproliterative effects against immortal PC3 cell lines. It was previously demonstrated that the effect can be enhanced when tethered to NO releasing groups such as nitrate esters, furoxans and sydnonimines. To explore this approach further, a total of fifty-six sulindac– ...