A practical one-pot synthesis of 2, 3-disubstituted indoles from unactivated anilines
M Tokunaga, M Ota, M Haga, Y Wakatsuki
Index: Tokunaga, Makoto; Ota, Mitsuru; Haga, Masa-aki; Wakatsuki, Yasuo Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3865 - 3868
Full Text: HTML
Citation Number: 63
Abstract
The indole skeleton is an important element in many pharmacologically active compounds and there is still a strong demand for a versatile, efficient, and regioselective synthesis. 1 The classical Fischer indole synthesis 2 has been used for more than 100 years and is the most common and versatile method known, but has difficulties associated with the use of arylhydrazine precursors to produce an arylhydrazone intermediate. Recently, this precursor has been elegantly ...
Related Articles:
[Sudhakara, Aralihalli; Jayadevappa, Honnali; Kumar, Hosanagara N.H.; Mahadevan, Kittappa M. Letters in Organic Chemistry, 2009 , vol. 6, # 2 p. 159 - 164]
SnCl2 2H2O-An alternative to Lewis acidic ionic liquids
[Arumugam, Pandurangan; Perumal, Paramasivan T. Chemistry Letters, 2006 , vol. 35, # 6 p. 632 - 633]
[Cabrera; Sharma; Ayala; Rubio-Perez; Amezquita-Valencia, Manuel Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6758 - 6762]
[Tursky, Matyas; Lorentz-Petersen, Linda L. R.; Olsen, Lasse B.; Madsen, Robert Organic and Biomolecular Chemistry, 2010 , vol. 8, # 24 p. 5576 - 5582]
[Akazome, Motohiro; Kondo, Teruyuki; Watanabe, Yoshihisa Journal of Organic Chemistry, 1994 , vol. 59, # 12 p. 3375 - 3380]