Palladium complex-catalyzed reductive N-heterocyclization of nitroarenes: novel synthesis of indole and 2H-indazole derivatives

M Akazome, T Kondo, Y Watanabe

Index: Akazome, Motohiro; Kondo, Teruyuki; Watanabe, Yoshihisa Journal of Organic Chemistry, 1994 , vol. 59, # 12 p. 3375 - 3380

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Citation Number: 136

Abstract

The dichlorobis (tripheny1phosphine) palladium (PdCl2 (PPh&-tin (II) chloride (SnC12) system shows high catalytic activity for the reductive N-heterocyclization of various 2- nitrostyrene and N-(2-nitrobenzy1idene) amine derivatives when employed at 100" C for 16 h under 20 kg cm-2 of initial carbon monoxide pressure, to give the corresponding indole and W-indazole derivatives in good yield. For example, 2-phenylindole was obtained in ...