Tetrahedron

The PdCl 2-catalyzed sequential heterocyclization/Michael addition cascade in the synthesis of 2, 3-disubstituted indoles

D Janreddy, V Kavala, CW Kuo, TS Kuo, CH He…

Index: Janreddy, Donala; Kavala, Veerababurao; Kuo, Chun-Wei; Kuo, Ting-Shen; He, Chiu-Hui; Yao, Ching-Fa Tetrahedron, 2013 , vol. 69, # 15 p. 3323 - 3330

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Citation Number: 13

Abstract

A cascade reaction of 2-N-unprotected-2-alkynylanilines and various electron-deficient alkenes in the presence of PdCl2 provided 2, 3-disubstituted indole derivatives, whereas, in the presence of Pd (OAc) 2, the same reaction resulted in the production of N-alkylated-2- alkynylaniline derivatives.

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