Ready synthesis of free NH 2-arylindoles via the copper-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular …

…, L Jiang, R Zhang, K Jin, D Zhao, C Duan

Index: Wang, Huifeng; Li, Yaming; Jiang, Linlin; Zhang, Rong; Jin, Kun; Zhao, Defeng; Duan, Chunying Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4983 - 4986

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Citation Number: 16

Abstract

A wide range of free NH 2-arylindoles were synthesised via the copper (II)-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization. The convenience and atom economy of aqueous ammonia, and the low cost of the copper catalytic system make this protocol readily superior in practical application.

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