“On Water” Direct and Site??Selective Pd??Catalysed C H Arylation of (NH)??Indoles

L Joucla, N Batail, L Djakovitch

Index: Joucla, Lionel; Batail, Nelly; Djakovitch, Laurent Advanced Synthesis and Catalysis, 2010 , vol. 352, # 17 p. 2929 - 2936

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Citation Number: 75

Abstract

Abstract This communication describes the development of a versatile catalytic system based on palladium (II) acetate/bis (diphenylphosphino) methane [Pd (OAc) 2/dppm] that works “on water” giving site-selective C [BOND] H arylation of (NH)-indoles without protecting or directing groups. Remarkably, the control of regioselectivity was achieved by small changes in the “extra-catalytic” base/halide partners. These innovative ...

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