Synthesis and biological evaluation of 2, 3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors
…, V Ravikumar, SV Rudrawar, P Daga, CS Rao…
Index: Singh, Sunil K.; Saibaba; Ravikumar; Rudrawar, Santosh V.; Daga, Pankaj; Rao, C. Seshagiri; Akhila; Hegde; Rao, Y. Koteswar Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1881 - 1893
Full Text: HTML
Citation Number: 53
Abstract
Several 2, 3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO2NH2)/methylsulfonyl (SO2Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity. Smaller groups such as methoxy, methyl and fluoro when substituted at/around position-4 of the adjacent phenyl ring, have great impact on the selective COX-2 inhibitory activity of the series. Many potential compounds ...
Related Articles:
Practical method for transforming alkynes into α-diketones
[Wan, Zhonghui; Jones, Chauncey D.; Mitchell, David; Pu, John Y.; Zhang, Tony Y. Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 826 - 828]
Antiinflammatory 4, 5-diarylimidazoles as selective cyclooxygenase inhibitors
[Barta, Thomas E.; Stealey, Michael A.; Collins, Paul W.; Weier, Richard M. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3443 - 3448]
The Absorption Spectra of Tetracyclones. IV1, 2
[Coan et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 60,62, 63]
Antiinflammatory 4, 5-diarylimidazoles as selective cyclooxygenase inhibitors
[Barta, Thomas E.; Stealey, Michael A.; Collins, Paul W.; Weier, Richard M. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3443 - 3448]
Antiinflammatory 4, 5-diarylimidazoles as selective cyclooxygenase inhibitors
[Barta, Thomas E.; Stealey, Michael A.; Collins, Paul W.; Weier, Richard M. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3443 - 3448]