Antiinflammatory 4, 5-diarylimidazoles as selective cyclooxygenase inhibitors
TE Barta, MA Stealey, PW Collins, RM Weier
Index: Barta, Thomas E.; Stealey, Michael A.; Collins, Paul W.; Weier, Richard M. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3443 - 3448
Full Text: HTML
Citation Number: 61
Abstract
Chemistry It has been recently discovered that the body contains at least two isoforms of cyclooxygenase: COX-1 and COX-2] COX-1 is thought to be involved in normal metabolic housekeeping, for example, cytoprotection of the stomach lining. COX-2 is present in inflamed tissues. Unselective cyclooxygenase inhibitors which disrupt the action of COX-l, such as aspirin and ibuprofen, can lead to stomach ulcers. This effect can be dose limiting in patients with ...
Related Articles:
Practical method for transforming alkynes into α-diketones
[Wan, Zhonghui; Jones, Chauncey D.; Mitchell, David; Pu, John Y.; Zhang, Tony Y. Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 826 - 828]
[Singh, Sunil K.; Saibaba; Ravikumar; Rudrawar, Santosh V.; Daga, Pankaj; Rao, C. Seshagiri; Akhila; Hegde; Rao, Y. Koteswar Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1881 - 1893]
The Absorption Spectra of Tetracyclones. IV1, 2
[Coan et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 60,62, 63]
[Singh, Sunil K.; Saibaba; Ravikumar; Rudrawar, Santosh V.; Daga, Pankaj; Rao, C. Seshagiri; Akhila; Hegde; Rao, Y. Koteswar Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1881 - 1893]
[Singh, Sunil K.; Saibaba; Ravikumar; Rudrawar, Santosh V.; Daga, Pankaj; Rao, C. Seshagiri; Akhila; Hegde; Rao, Y. Koteswar Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1881 - 1893]