Cascade Formation of Isoxazoles: Facile Base??Mediated Rearrangement of Substituted Oxetanes
JA Burkhard, BH Tchitchanov…
Index: Burkhard, Johannes A.; Tchitchanov, Boris H.; Carreira, Erick M. Angewandte Chemie - International Edition, 2011 , vol. 50, # 23 p. 5379 - 5382
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Citation Number: 43
Abstract
Heterocycles play an important role in pharmaceutical sciences and many other areas of organic chemistry. Among the most widely employed nitrogen-containing five-membered rings are the isoxazoles. Their preparation has been extensively discussed in the literature and typical access routes involve condensations with hydroxylamine, cyclizations of ketoxime dianions, and propargylic oximes, and in particular 1, 3-dipolar cycloaddition ...
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