Rhodium??Catalyzed Asymmetric Hydroformylation of 1, 1??Disubstituted Allylphthalimides: A Catalytic Route to β3??Amino Acids

X Zheng, B Cao, T Liu, X Zhang

Index: Zheng, Xin; Cao, Bonan; Liu, Tang-Lin; Zhang, Xumu Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 679 - 684

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Citation Number: 8

Abstract

Abstract The high enantioselective rhodium-catalyzed hydroformylation of 1, 1-disubstituted allylphthalimides has been developed. By employing chiral ligand 1, 2-bis [(2S, 5S)-2, 5- diphenylphospholano] ethane [(S, S)-Ph-BPE], a series of β 3-aminoaldehydes can be prepared with up to 95% enantioselectivity. This asymmetric procedure provides an efficient alternative route to prepare chiral β 3-amino acids and alcohols.