Bulletin of the Chemical Society of Japan

NAD (P)+-NAD (P) H model. 39. Asymmetric reduction by 1, 4-dihydronicotinamide derivative bound to protein

A Ohno, S Ushida, S Oka

Index: Ohno, Atsuyoshi; Ushida, Satoshi; Oka, Shinzaburo Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 2 p. 564 - 567

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Citation Number: 7

Abstract

1, 4-Dihydronicotinamide derivatives covalently bound to NH 2 or SH group of proteins such as reduced keratin (RK), egg white albumin (EWA), and bovine serum albumin (BSA) have been synthesized and subjected to the reductions of α, α, α-trifluoroacetophenone derivatives. Chiral alcohol is obtained in the reaction with 1, 4-dihydronicotinamide modified by the SH group of BSA.