Intramolecular N-arylation in heterocyclization: synthesis of new pyrido-fused pyrrolo [1, 2-a][1, 4] diazepinones
L Legerén, D Domínguez
Index: Legeren, Loreto; Dominguez, Domingo Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4053 - 4057
Full Text: HTML
Citation Number: 8
Abstract
Alkylation of l-prolinamide with 3-(chloromethyl)-2-halopyridines, followed by cyclization through an intramolecular Pd-catalysed amidation, provided an entry to the pyrido [2, 3-e] pyrrolo [1, 2-a][1, 4] diazepin-10-one scaffold. Furthermore, a synthetic route towards diverse new pyrido [f] pyrrolo [1, 2-a][1, 4] diazepin-7-ones has been developed by acylation of contiguously substituted (aminomethyl) halopyridines with Boc-l-proline followed by ...
Related Articles:
[Spivey, Alan C.; Shukla, Lena; Hayler, Judy F. Organic Letters, 2007 , vol. 9, # 5 p. 891 - 894]
[Organic Letters, , vol. 9, # 5 p. 891 - 894]
Synthesis of Biaryls by Intramolecular Radical Transfer in Phosphinates
[Journal of Organic Chemistry, , vol. 66, # 18 p. 6083 - 6091]
[Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458]