Eco-friendly synthesis of 1, 4-benzodiazepine-2, 5-diones in the ionic liquid [bmim] Br
…, D Asgari, P Eslami, H Arvin-Nezhad
Index: Jadidi, Khosrow; Ghahremanzadeh, Ramin; Asgari, Davoud; Eslami, Parisa; Arvin-Nezhad, Hamid Monatshefte fur Chemie, 2008 , vol. 139, # 10 p. 1229 - 1232
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Citation Number: 4
Abstract
Abstract The green reaction of isatoic anhydrides with α-amino acids in presence of the ionic liquid 1-butyl-3-methylimidazolium bromide afforded 1, 4-benzodiazepine-2, 5-diones in excellent yields in absence of a catalyst. The reaction workup is simple and the ionic liquid was easily recovered from the reaction and reused. The methodology was quite general and a range of cyclic and acyclic α-amino acids were examined to produce 1, 4- ...
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