Lysine N ε-trimethylation, a tool for improving the selectivity of antimicrobial peptides

…, M Valles-Miret, J Jiménez-Barbero…

Index: Fernandez-Reyes, Maria; Diaz, Dolores; De La Torre, Beatriz G.; Cabrales-Rico, Ania; Valles-Miret, Mariona; Jimenez-Barbero, Jesus; Andreu, David; Rivas, Luis Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5587 - 5596

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Citation Number: 15

Abstract

The effects of lysine N ε-trimethylation at selected positions of the antimicrobial cecropin A− melittin hybrid peptide KWKLFKKIGAVLKVL-amide have been studied. All five monotrimethylated, four bis-trimethylated plus the per-trimethylated analogues have been synthesized and tested for antimicrobial activity on Leishmania parasites and on Gram- positive and-negative bacteria, as well as for hemolysis of sheep erythrocytes as a ...